The glass-skin glow you save up for at the spa — now in a bottle you can reach for every morning. NATUDERMA™ PDRN-4D Glass Skin Pro Serum is a silky, lightweight PDRN serum inspired by Korean skincare, made for both professional post-care and daily home use. Bio-fermented vegan PDRN, 4D Hyaluronic Acid, and Niacinamide work together to refresh the look of over reacting skin, support a healthy-looking barrier, and leave skin dewy, smooth, and luminous.
Key Benefits
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Bio-Fermented Vegan PDRN (<100bp): Powered by L-PDRN First™, an ultra-small vegan DNA complex that absorbs quickly to support the look of skin density and vitality.
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4D Multi-Layer Hydration: 2% 4D Hyaluronic Acid draws moisture to multiple layers of the skin for lasting hydration and a plumper, more elastic feel.
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Tone & Texture Refining: 2% Niacinamide helps even the look of skin tone, smooth texture, and support the moisture barrier.
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Post-Care Comfort: Soothes and comforts skin after non-invasive treatments like peels, microdermabrasion, or micro-channeling.
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Clean Formula: 100% Vegan, Cruelty-Free, Paraben-Free, Phthalate-Free, and Unscented.
Key Ingredients
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2% L-PDRN First™: A low-molecular-weight (<100bp) plant-derived complex produced via Lactobacillus fermentation that supports barrier function, vitality, and skin renewal.
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2% Hyaluronic Acid 4D Matrix: A multi-weight complex that hydrates from the surface to deeper-looking layers.
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2% Niacinamide (Vitamin B3): Boosts the look of brightness, helps minimize the appearance of pores, and improves clarity.
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Pro-Vitamin B5 (Panthenol) & Organic Aloe: Soothe and condition reactive or stressed-looking skin.
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Botanical Nourishing Complex: Organic Cucumber, Chamomile, Papaya, Rose Water, and Rice extracts add antioxidant comfort against daily environmental stress.
Why L-PDRN First™
Traditional PDRN is often sourced from marine sources with larger molecules (200–800bp). NATUDERMA™ uses L-PDRN First™, a sustainable, vegan DNA fragment (<100bp) produced through Lactobacillus rhamnosus fermentation:
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Fast Absorption: Its ultra-small size (<100bp) helps it sink in quickly for a lightweight, comfortable finish.
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Vegan & Sustainable: A cruelty-free alternative to animal-derived PDRN, made through clean fermentation.
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Antioxidant Comfort: Helps defend the look of skin against everyday environmental stress.
4D Hyaluronic Acid Moisture Technology
Instead of sitting only on the surface, 4D Hyaluronic Acid creates a multi-dimensional moisture network that targets different layers of the skin for hydration that lasts and a smoother, more elastic feel.
| HA Form |
What It Does |
| Sodium Hyaluronate Crosspolymer |
Forms a soft, cushioning moisture film on the surface to help reduce water loss and shield against daily pollutants. |
| Sodium Hyaluronate |
Holds water on the surface to continually nourish the outer layer. |
| Sodium Acetylated Hyaluronate |
Adheres to the outer layer for long-lasting hydration while smoothing the look of dry, rough texture. |
| Hydrolyzed Sodium Hyaluronate |
A micro-sized molecule that absorbs quickly to hydrate and restore a plumper look from within. |
Product Specifications
| Net Volume |
1.0 fl. oz. (30 mL) |
| Key Actives |
2% L-PDRN First™ Solution, 2% 4D Hyaluronic Acid, 2% Niacinamide |
| Texture |
Unscented, silky, fast-absorbing serum |
| Skin Types |
Suitable for all skin types, including sensitive and post-procedure skin |
| Formulation Standard |
Paraben-Free, Phthalate-Free, Vegan, Made in USA |
How to Use — At Home & In the Treatment Room
Daily At-Home Routine
Apply 4–6 drops to clean face and neck twice daily (AM/PM). Massage gently upward until fully absorbed. Follow with your moisturizer and, in the morning, a broad-spectrum sunscreen.
Professional & Post-Facial Care
Apply after facial to soothern and support the skin barrier.
For Aesthetic Professionals
Pair with our PDRN-HA Microneedling Serum (Box of 5 Vials): use the PDRN-HA vials during in-clinic micro-channeling, then send clients home with the PDRN-4D Glass Skin Pro Serum for daily maintenance that keeps skin hydrated and glowing between sessions.
FAQ
Why vegan PDRN instead of salmon (fish) DNA?
Most PDRN on the market comes from salmon or trout DNA. Our L-PDRN First™ is a plant-friendly, vegan alternative made through clean Lactobacillus rhamnosus fermentation — so there's no fish-derived material, no marine sourcing concerns, and no fishy scent. Its molecules are also much smaller (<100bp vs. the typical 200–800bp of marine PDRN), which helps it absorb quickly for a lightweight, comfortable finish. You get the modern PDRN experience in a formula that's cruelty-free, sustainable, and suitable for those who avoid animal-derived ingredients.
What makes 4D Hyaluronic Acid different from standard Hyaluronic Acid?
Standard HA often stays on the surface. 4D Hyaluronic Acid blends four molecular weights in one network — shielding the surface, conditioning the top layer, and hydrating deeper-looking layers for a fuller, dewier finish.
Is this serum for daily home use or professional clinics?
Both. Aesthetic professionals use it as a post-treatment finishing serum, while clients use it daily at home as a high-performance hydrating serum.
How does it complement the PDRN-HA Microneedling Serum?
Use the PDRN-HA Vials-serum for aesthetic microneedling or micro-channeling facial. The PDRN-4D Glass Skin Serum is the daily follow-up that keeps skin hydrated, comfortable, and glowing between sessions.
Is it suitable for sensitive skin?
Yes. It's fragrance-free, unscented, and enriched with soothing botanicals like chamomile, cucumber, aloe, and panthenol to help calm reactive skin.
Ingredients
Full INCI List: Water (Aqua), Glycerin, Niacinamide, Panthenol (Pro-Vitamin B5), Sodium Hyaluronate (Hyaluronic Acid), Organic Aloe Barbadensis Leaf Extract, Rosa Damascena (Rose) Flower Water, Lactobacillus Ferment Lysate, Hydrolyzed DNA, Sodium DNA, Phenoxyethanol, 1,2-Hexanediol, Sodium Chloride, Ethylhexylglycerin, Cucumis Sativus (Cucumber) Fruit Extract, Chamomilla Recutita (Matricaria) Flower Extract, Carica Papaya Fruit Extract, Citric Acid, Tetrasodium Glutamate Diacetate, Oryza Sativa (Rice) Extract.
Disclaimer
For external use only. Avoid direct contact with eyes. Discontinue use if irritation or discomfort occurs. Keep out of reach of children. Perform a patch test before first use if you have sensitive or reactive skin. This product is a cosmetic and is not intended to diagnose, treat, cure, or prevent any disease or medical condition. Individual results may vary.
