In the rapidly evolving landscape of regenerative medicine, the distinction between Polynucleotides (PN) and Polydeoxyribonucleotides (PDRN) has become the definitive marker of an expert practitioner. While both originate from salmon DNA, their structural "personalities" dictate entirely different clinical outcomes.

The Architectural Difference between Polynucleotides (PN) and Polydeoxyribonucleotides (PDRN)

The core difference lies in their polymer chain length and molecular weight.

• PN (Polynucleotides): These are longer chains of DNA fragments with high molecular weight. They act as a structural scaffold, creating a 3D hydrogel in the dermis that provides long-lasting volume and hydration.
• PDRN: Composed of shorter oligonucleotide sequences, PDRN is a lightweight powerhouse. It is highly fluidic and excels at targeted cellular signaling and rapid repair via the adenosine A2A receptor.

Clinical Comparison Table

The Benefits: Why Use PDRN and PN?

PDRN: The Cellular Repair Engine

PDRN acts as a "bio-activator." By engaging the nucleotide salvage pathway, it provides the raw materials for cells to repair their own DNA, which is particularly vital for skin damaged by UV radiation or aging.

• Anti-Inflammatory: Rapidly downregulates pro-inflammatory cytokines like TNF-$\alpha$ and IL-6.
• Wound Healing: Accelerates tissue repair by promoting angiogenesis (new blood vessel growth).
• Pigment Control: Helps manage hyperpigmentation by suppressing tyrosinase activity.
• Hair Regrowth: Emerging evidence shows it improves hair density and thickness.

PN: The Architectural Sculptor

PN is more about the "environment." Its long-chain structure creates a physical scaffold in the skin.

• Intense Hydration: Its high water-binding capacity restores skin viscosity and "glow".
• Structural Integrity: Excellent for periorbital (eye) rejuvenation, improving fine lines, and skin roughness.
• Scaffold Effect: Creates a favorable microenvironment for the production of new collagen and the Extracellular Matrix (ECM).

Choosing between Natuderma PDRN-HA and Natuderma Exosomes HA, Treatment Strategies

With the Natuderma line, you can customize your microneedling protocols based on the patient's primary concern.

1. The "Heavy Repair & Refresh" Protocol: Natuderma PDRN-HA

• Best For: Rough skin, dullness, fine wrinkles, and those seeking "glass skin".
• Key Ingredients: Contains PDRN for revitalization, Sodium Hyaluronate for deep hydration, and Japanese Orchid Stem Cells to help contour the jawline and eye area.
• The Logic: Use this when the goal is to refine texture and provide a lifted, refreshed appearance via gentle conditioners like Gluconolactone.

2. The "Total Rejuvenation & Regeneration" Protocol: Natuderma Exosomes HA

• Best For: Advanced anti-aging, significant skin damage, and scalp/hair wellness.
• Key Ingredients: A powerhouse blend of PN and PDRN (Sodium DNA and Hydrolyzed DNA/RNA), combined with Exosomes from Centella Asiatica and Rosa Centifolia.
• The Logic: This offers the ultimate regenerative synergy. The PN/PDRN duo handles repair and structural hydration, while Exosomes deliver growth factors to nourish and support skin regeneration.

The Professional Tip

Choose PN when your patient needs a "rebuild" of their skin’s architecture. Opt for PDRN when the goal is "rescue" healing fragile skin, reducing redness, or accelerating post-procedure recovery.